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. 2019 Jul 2;20:541. doi: 10.1186/s12864-019-5932-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The correlation of histone modification codes with gene expression. (a) Distributions of the numbers of the trivalent histone mark “T” and all codes at the upstream (up), downstream (down), and combined both upstream and downstream (total) surrounding TSS. (b) Correlation of gene expression levels (RPKM) with the number of single and multivalent histone marks within ±2 kb of the TSS for all genes in HepG2 cells. T, H3K4me3/H3K9ac/H3K27ac; D, H3K4me3/H3K9ac; A, H3K4me3. (c) The violin plot of the expression values of all genes in each cluster. Black dots, the median expression levels. (d) The correlation between gene expression values and numbers of the trivalent histone mark “T” and all codes at the upstream, downstream, and combined both upstream and downstream (total) surrounding TSS. Gene expression values and histone counts are median values from Fig. 4c and a, respectively