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. 2019 Jul 2;12:39. doi: 10.1186/s13072-019-0286-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — BET proteins displacement from chromatin is compound dose dependent. a Proliferation assays in sensitive (MV4;11) and resistant (K562) cells treated with increasing concentrations of I-BET151. Compound IC50 (M) or compound concentration which induces 50% inhibition of cell viability as well as the response area (see “Materials and methods” section for the calculation) is shown below the graph. b Experimental design followed in the study and I-BET151 structure. c Bar plot showing the ChIP-qPCR enrichment relative to DMSO for the ZC3H4 locus in K562 and MV4;11 for cells treated with three concentrations of I-BET151 and DMSO as a control. d Barplot showing the number of peaks called for BRD4 at TSS for cells treated with three concentrations of I-BET151 and DMSO as a control and for both cell lines