Table 1.
Histology of lateral and posterior columns of spinal cord in 7 different time points, from 10 min till 360 days, after spinal cord injury
| Treatment group | Time after spinal cord injury (min/med/max) | |||||||
|---|---|---|---|---|---|---|---|---|
| 10 min. | 7 days | 15 days | 30 days | 90 days | 180 days | 360 days | ||
|
Control saline 5 ml/kg b.w. i.p. |
Hemorrhage | 2/2.5/3 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 |
| Vacuoles | 0/0/0 | 2/2.5/3 | 1/3/3 | 2/2/2 | 2/2/2 | 2/2.5/3 | 2/2.5/3 | |
| Necrosis | 0/0/0 | 1/2.5/3 | 2/3/3 | 2/3/3 | 2/3/3 | 1/3/3 | 1/3/3 | |
| Pentadecapeptide BPC 157 200 μg/kg b.w. i.p. | Hemorrhage | 2/2.5/3 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 |
| Vacuoles | 0/0/0 | 1/1/1* | 1/1/1* | 0/1/2* | 1/1/1* | 1/1/2* | 1/2/2* | |
| Necrosis | 0/0/0 | 0/2/2 | 0/0/2* | 1/1/2* | 0/0/1* | 1/1/1* | 0/0/1 | |
| Pentadecapeptide BPC 157 2 μg/kg b.w. i.p. | Hemorrhage | 2/2.5/3 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 |
| Vacuoles | 0/0/0 | 1/1/1* | 1/1/1* | 0/1/2* | 1/1/1* | 1/1/2* | 1/2/2* | |
| Necrosis | 0/0/0 | 0/2/2 | 0/0/2* | 1/1/2* | 0/0/1* | 1/1/1* | 0/0/1 | |
| Laminectomy | Hemorrhage | – | – | – | – | – | – | 0/0/0 |
| Vacuoles | – | – | – | – | – | – | 0/0/0 | |
| Necrosis | – | – | – | – | – | – | 0/0/0 | |
Semiquantitatively evaluated intensity of (a) hemorrhagic zone, (b) vacuoles, and (c) loss of tracts in lateral and posterior columns of spinal cord (0—no changes; 1—small or focal changes; 2—moderate changes; 3—numerous confluent changes)
*Statistically significant difference BPC 157 groups vs control group, P < 0.025