Table 2.
Histology of anterior horn and intermediate gray matter of spinal cord in 7 different time points, from 10 min till 360 days, after spinal cord injury
| Treatment group | Time after spinal cord injury (min/med/max) | |||||||
|---|---|---|---|---|---|---|---|---|
| 10 min. | 7 days | 15 days | 30 days | 90 days | 180 days | 360 days | ||
|
Control saline 5 ml/kg b.w. i.p. |
Hemorrhage | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 |
| Edema | 0/0/0 | 1/1.5/2 | 1/3/3 | 3/3/3 | 3/3/3 | 3/3/3 | 3/3/3 | |
| Necrosis | 0/0/0 | 1/1.5/2 | 1/3/3 | 3/3/3 | 3/3/3 | 3/3/3 | 3/3/3 | |
| Pentadecapeptide BPC 157 200 μg/kg b.w. i.p. | Hemorrhage | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 |
| Edema | 0/0/0 | 0/1/1 | 0/1/1* | 0/1/3* | 1/1/1* | 1/1/1* | 2/2/2* | |
| Necrosis | 0/0/0 | 0/1/1 | 1/1/1 | 0/1/3* | 0/0/2* | 3/3/3 | 3/3/3 | |
| Pentadecapeptide BPC 157 2 μg/kg b.w. i.p. | Hemorrhage | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 | 0/0/0 |
| Edema | 0/0/0 | 0/1/1 | 0/0/2* | 1/2/2* | 1/1/1* | 1/1/1* | 2/2/2* | |
| Necrosis | 0/0/0 | 1/1/1 | 0/0/3 | 1/2/2* | 0/0/2* | 3/3/3 | 3/3/3 | |
| Laminectomy | Hemorrhage | – | – | – | – | – | – | 0/0/0 |
| Edema | – | – | – | – | – | – | 0/0/0 | |
| Necrosis | – | – | – | – | – | – | 0/0/0 | |
Semiquantitatively evaluated intensity of (a) hemorrhagic zone, (b) edema, and (c) loss of neurons in anterior horn and intermediate gray matter of spinal cord (0—no changes; 1—small or focal changes; 2—moderate changes; 3—numerous confluent changes)
*Statistically significant difference between both pentadecapeptide BPC 157 groups and control group, P < 0.025