Table 3.
Average methylation of HIF3A.1 and HIF3A.2 by genotype for each of the 14 tag SNPs considered in this analysis
| SNP | HIF3A.1 methylation (n = 410) | HIF3A.2 methylation (n = 595) | ||||
|---|---|---|---|---|---|---|
| rs62111812 | Mean (SD) | n | p | Mean (SD) | n | p |
| G/G | 70.02 (4.59) | 313 | 0.22 | 37.95 (9.96) | 438 | 0.1 |
| G/A | 70.93 (4.74) | 89 | 39.93 (8.74) | 144 | ||
| A/A | 71.19 (1.71) | 8 | 39.47 (10.37) | 13 | ||
| rs112087991 | ||||||
| T/T | 70.39 (4.47) | 359 | 0.22 | 39.46 (9.44) | 522 | < 0.0001 |
| T/C | 69.18 (5.38) | 49 | 31.54 (8.67) | 70 | ||
| C/C | 69.57 (0.61) | 2 | 27.17 (8.30) | 3 | ||
| rs8102595 | ||||||
| A/A | 69.97 (4.60) | 331 | 0.04 | 38.63 (9.83) | 477 | 0.7 |
| A/G | 71.37 (4.46) | 76 | 37.79 (9.28) | 115 | ||
| G/G | 72.07 (2.20) | 3 | 37.56 (9.56) | 3 | ||
| rs3826795 | ||||||
| C/C | 70.65 (4.18) | 250 | 0.07 | 40.42 (9.14) | 364 | < 0.0001 |
| C/T | 69.68 (5.23) | 142 | 35.76 (9.45) | 196 | ||
| T/T | 69.03 (4.16) | 18 | 33.28 (11.52) | 35 | ||
| rs3810298 | ||||||
| C/C | 70.42 (4.27) | 337 | 0.26 | 40.32 (9.02) | 476 | < 0.0001 |
| C/T | 69.44 (5.95) | 67 | 31.84 (8.63) | 109 | ||
| T/T | 69.44 (4.36) | 6 | 22.26 (5.88) | 10 | ||
| rs140454328 | ||||||
| T/T | 70.26 (4.61) | 398 | 0.71 | 38.49 (9.72) | 563 | 0.87 |
| T/C | 69.75 (4.01) | 12 | 38.08 (9.90) | 31 | ||
| C/C | – | 0 | 33.83 (0) | 1 | ||
| rs36063219 | ||||||
| C/C | 70.23 (4.63) | 393 | 0.78 | 38.41 (9.76) | 576 | 0.46 |
| C/T | 70.55 (3.80) | 17 | 40.08 (8.39) | 19 | ||
| T/T | – | 0 | – | 0 | ||
| rs3752207 | ||||||
| C/C | 70.23 (4.43) | 357 | 0.21 | 38.31 (9.54) | 516 | 0.29 |
| C/A | 70.66 (4.95) | 48 | 39.06 (11.02) | 72 | ||
| A/A | 66.83 (10.11) | 5 | 43.75 (7.81) | 7 | ||
| rs4803929 | ||||||
| C/C | 70.13 (4.64) | 355 | 0.04 | 38.6 (9.78) | 510 | 0.29 |
| C/T | 70.7 (4.01) | 53 | 37.41 (9.25) | 83 | ||
| T/T | 77.88 (4.77) | 2 | 46.49 (8.69) | 2 | ||
| rs9304657 | ||||||
| T/T | 70.34 (4.00) | 181 | 0.75 | 38.31 (10.18) | 288 | 0.92 |
| T/C | 70.27 (5.00) | 178 | 38.58 (9.48) | 237 | ||
| C/C | 69.80 (5.12) | 51 | 38.72 (8.58) | 70 | ||
| rs76789866 | ||||||
| T/T | 70.26 (4.58) | 385 | 0.82 | 38.83 (9.61) | 546 | 0.01 |
| T/C | 70.04 (4.79) | 25 | 34.29 (9.85) | 47 | ||
| C/C | – | 0 | 37.43 (17.94) | 2 | ||
| rs75952656 | ||||||
| T/T | 70.28 (4.67) | 382 | 0.54 | 38.32 (9.70) | 558 | 0.15 |
| T/A | 69.73 (3.29) | 28 | 40.71 (9.81) | 37 | ||
| A/A | – | 0 | – | 0 | ||
| rs917946 | ||||||
| A/A | 70.25 (4.58) | 328 | 0.96 | 38.07 (9.51) | 477 | 0.05 |
| A/G | 70.23 (4.72) | 79 | 39.74 (10.47) | 111 | ||
| G/G | 69.44 (2.17) | 3 | 45.28 (7.40) | 7 | ||
| rs12459580 | ||||||
| G/G | 70.08 (4.19) | 119 | 0.65 | 38.71 (8.36) | 168 | 0.93 |
| G/C | 70.44 (4.74) | 212 | 38.36 (9.89) | 295 | ||
| C/C | 69.95 (4.77) | 79 | 38.39 (10.91) | 132 | ||
p value is from one-way ANOVA. SD standard deviation