Table 1.
Baseline cardiac function of ex vivo perfused hearts with or without phlorizin-perfusion
| NFD (n = 6) |
NFD-phlorizin (n = 6) |
HFD (n = 8) |
HFD-phlorizin (n = 8) |
|
|---|---|---|---|---|
| LVSP, mmHg | 98.9 ± 5.1 | 112 ± 8.5 | 119 ± 4.9* | 133 ± 11* |
| LVEDP, mmHg | 9.2 ± 0.4 | 10 ± 0.8 | 9.6 ± 0.2 | 9.4 ± 0.5 |
| LVDP, mmHg | 89.8 ± 5.1 | 102 ± 8.9 | 109 ± 5.0* | 123 ± 11* |
| +dp/dt, mmHg/s | 2742 ± 247 | 3277 ± 308 | 3478 ± 162 | 4098 ± 463 |
| −dp/dt, mmHg/s | − 2308 ± 200 | − 2450 ± 277 | − 2814 ± 177 | − 3380 ± 518 |
| HR, bpm | 272 ± 44 | 306 ± 35 | 266 ± 27 | 284 ± 22 |
| RPP, mmHg bpm | 25,429 ± 5192 | 31,251 ± 4897 | 28,650 ± 2714 | 35,970 ± 5245 |
| Coronary flow, mL/min | 3.30 ± 0.47 | 2.93 ± 0.36 | 3.19 ± 0.32 | 3.58 ± 0.38 |
NFD normal fat diet, HFD high fat diet, LVSP left ventricular systolic pressure, LVEDP left ventricular end-diastolic pressure, LVDP left ventricular developed pressure, HR heart rate, RPP rate pressure product
*P < 0.05 versus NFD group