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. 2019 Jul 2;20:539. doi: 10.1186/s12864-019-5926-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — QQ plots of simulated null p-values for genes in TCGA HNSC study. (A) Histogram and density plot of RPKM for each genes. (B) Corresponding QQ plot of null p-values simulated by shuffling the samples for lncDIFF, DESeq2, edgeR and limma. (C) Corresponding QQ plot of null p-values simulated by shuffling the samples for lncDIFF, zinbwave+DESeq2, DEsingle and ShrinkBayes