Table 3.

Estimated group effect on a gene by lncDIFF on simulated low-abundance expression. Low-abundance expressions were sampled from three statistical distributions and two scenarios of parameters (defined by β ’s and CV). 1000 replicates were generated resulting in 1000 estimates per scenario

Sampling Distribution	Groups	Baseline Group A	Contrast B vs A	Contrast C vs A	Baseline Group A	Contrast B vs A	Contrast C vs A
	True Parameter	βi1 = 2 (CV = 1.75)	βi2 = 3 (CV = 1.45)	βi2 = 8 (CV = 1.26)	βi1 = 2 (CV = 1)	βi2 = 3 (CV = 0.7)	βi2 = 8 (CV = 0.6)
Exponential (CV = 1)	Mean	1.98	3.03	7.91	1.98	3.03	7.91
	Median	1.97	3.02	7.85	1.97	3.02	7.85
Negative Binomial	Mean	1.99	3.00	8.03	2.00	3.01	8.06
	Median	1.98	2.96	7.97	2.00	3.01	8.02
Log Normal	Mean	1.99	2.99	7.98	1.99	3.00	8.02
	Median	1.95	2.92	7.82	1.97	2.95	7.95