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. 2019 Jul 1;24:47. doi: 10.1186/s11658-019-0168-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — EIF4A2 is a direct target of miR-5195-3p. a The binding sites of EIF4A2 and miR-5195-3p were predicted using bioinformatics analysis. b and c The luciferase reporter assay was performed in paclitaxel-resistant BT549/PTX and MDA-MB-231/PTX cells. d and e Quantitative real-time PCR and western blot assays were used to analyze the expression of EIF4A2 after transfection of miR-5195-3p mimics and miR-NC. f The expression of EIF4A2 was determined via quantitative real-time PCR in 18 paclitaxel-sensitive and 18 paclitaxel-resistant tissues. g Spearman rank correlation analysis showed an inverse correlations between the expression levels of EIF4A2 and miR-5195-3p in paclitaxel-resistant breast cancer tissues. **p < 0.01 vs. miR-NC