Table 1.
Effect of treatment with simvastatin on DNA damage, liver integrity, total cholesterol, and triglyceride serum levels and hepatic lipids in mice livers with NASH induced by a MCD diet.
| CO+V | SIM 4 | NASH+V | NASH+SIM 4 | |
|---|---|---|---|---|
| DI | 58.5 ± 15.7 | 61.68 ± 12.34 | 111 ± 17 ± 16.97∗ | 85.40 ± 18.82 |
| AST (U/L) | 69.14 ± 13.38 | 74.1 ± 14.50 | 354.0 ± 62.29# | 303.7 ± 42.15# |
| ALT (U/L) | 30.75 ± 7.52 | 33.8 ± 7.69 | 404.0 ± 53.66#$ | 369.0 ± 39.34#$ |
| Total Cholesterol (mg/dL) | 129.9 ± 13.70 | 123.1 ± 13.50 | 28.5 ± 7.73# | 22.5 ± 4.07# |
| Triglyceride (mg/dL) | 67.00 ± 11.88 | 64.30 ± 8.73 | 33.6.5 ± 3.70# | 28.5 ± 2.49# |
| Cholesterol hepatic (mg cholesterol/mg tissue) | 0.19 ± 0.03 | 0.20 ± 0.03 | 0.40±0.10∗∗ | 0.20 ± 0.02 |
| Triglyceride hepatic (mg triglyceride/mg tissue) | 1.54 ± 0.45 | 1.30 ± 0.42 | 2.2±0.35∗∗ | 1.7 ± 0.43 |
CO+V: control plus vehicle (n = 8); SIM 4: control plus simvastatin 4 mg/kg (n = 8); NASH+V: NASH plus vehicle (n = 8); NASH+SIM 4: NASH plus simvastatin 4 mg/kg (n = 8). The data are expressed as the mean ± standard deviation (S.D); DI: damage index, which can range from 0 (completely undamaged, 100 cells × 0) to 400 (with maximum damage 100 × 4). ∗P < 0.05 CO+V versus NASH+V. #P < 0.001 versus CO+V and SIM 4. $P < 0.05 versus NASH+V. ∗∗P < 0.05 versus CO+V and SIM 4.