Table 3.

Effect of treatment with simvastatin on lipid peroxidation, SOD, and Gpx activities in mouse livers with NASH induced by a MCD diet.

	CO+V	SIM 4	NASH+V	NASH+SIM 4
TBARS (nmoles/mg prot)	0.11 ± 0.01	0.1 ± 0.03	0.45 ± 0.12∗	0.19 ± 0.02$
SOD (U/SOD mg prot)	50.52 ± 12.22	48.9 ± 7.05	33.72 ± 8.74∗	50.8 ± 10.92
GPx (nmoles/mg prot)	180.06 ± 57.69	181.59 ± 50.77	114.88 ± 19.46#	170.62 ± 34.39

CO+V: control plus vehicle (n = 8); SIM 4: control plus simvastatin 4 mg/kg (n = 8); NASH+V: NASH plus vehicle (n = 8); NASH+SIM 4: NASH plus simvastatin 4 mg/kg (n = 8). ^∗P < 0.001 versus CO+V, SIM 4, and NASH+V. ^$P < 0.01 against versus CO+V, SIM 4, and CO+V. ^#P < 0.05 versus CO+V, SIM 4, and NASH+V.