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. 2019 Jul 1;20:117. doi: 10.1186/s12881-019-0854-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Osteogenic differentiation of human BM-MSCs was increased by miR-148b-3p overexpression. (a-f) Representative micrograph of 14-day incubation of human BM-MSCs exposed to LV-Ctrl, LV-miR-148b-3p or LV-miR-148b-5p. Immunostaining of ALP and ColI with nuclear counterstained (Hoechst) were shown in red and blue respectively. It should be mentioned that EGFP+ cells were in green. (g-h)BM-MSCs overexpressed miR-148b-3p demonstrated 2.2- and 2.5-fold enhancement in ALP and ColI expression respectively compared to other groups. ****shows significant differences (P < 0.0001) between LV-miR-148b-3pwith LV-miR-148b-5p and LV-Ctrl