Table 3.

Multivariate analysis of possible predictors of silent brain infarct

	Crude OR (95% CI)	P-value	Adjusted OR (95% CI)	P-value
Total
Agea	2.28 (1.98 to 2.63)	<  0.001	1.10 (1.09 to 1.12)	<  0.001
Sex	1.07 (0.83 to 1.38)	0.608	1.02 (0.75 to 1.39)	0.890
Hypertension	2.02 (1.55 to 2.65)	<  0.001	1.17 (0.83 to 1.65)	0.037
Diabetes	1.94 (1.42 to 2.64)	<  0.001	1.31 (0.90 to 1.89)	0.157
On antiplatelet medication	1.70 (1.19 to 2.43)	0.003	1.20 (0.80 to 1.79)	0.372
hs-CRPa	1.12 (1.03 to 1.21)	0.008	1.07 (0.96 to 1.18)	0.219
ICAS	2.14 (1.21 to 3.77)	0.009	0.94 (0.44 to 2.00)	0.865
LDL cholesterola	0.83 (0.71 to 0.96)	0.012	0.96 (0.83 to 1.13)	0.637
TG/HDL cholesterol ratioa	1.13 (1.01 to 1.26)	0.030	1.16 (1.00 to 1.34)	0.047
Male
Agea	2.44 (2.02 to 2.94)	<  0.001	1.11 (1.08 to 1.14)	<  0.001
Hypertension	2.27 (1.60 to 3.22)	<  0.001	1.44 (0.92 to 2.24)	0.111
Diabetes	1.69 (1.13 to 2.52)	0.010	1.14 (0.71 to 1.85)	0.587
On antiplatelet medication	1.99 (1.30 to 3.07)	0.002	1.31 (0.79 to 2.16)	0.294
hs-CRPa	1.17 (1.06 to 1.29)	0.002	1.08 (0.96 to 1.22)	0.206
ICAS	2.06 (0.95 to 4.46)	0.068	1.28 (0.49 to 3.32)	0.617
LDL cholesterola	0.74 (0.60 to 0.90)	0.003	0.94 (0.76 to 1.17)	0.590
TG/HDL cholesterol ratioa	1.08 (0.94 to 1.24)	0.289	1.23 (1.03 to 1.48)	0.021
Female
Agea	2.09 (1.69 to 2.59)	<  0.001	1.09 (1.06 to 1.12)	<  0.001
Hypertension	1.72 (1.13 to 2.62)	0.012	0.88 (0.51 to 1.54)	0.656
Diabetes	2.40 (1.47 to 3.93)	<  0.001	1.72 (0.95 to 3.11)	0.073
On antiplatelet medication	1.22 (0.64 to 2.35)	0.546	0.92 (0.45 to 1.86)	0.811
hs-CRPa	1.01 (0.84 to 1.23)	0.898	1.02 (0.82 to 1.27)	0.848
ICAS	2.24 (0.98 to 5.15)	0.057	0.67 (0.19 to 2.39)	0.532
LDL cholesterola	0.95 (0.76 to 1.19)	0.657	1.00 (0.80 to 1.26)	0.989
TG/HDL cholesterol ratioa	1.26 (1.03 to 1.53)	0.023	1.06 (0.82 to 1.36)	0.672

hs-CRP high-sensitivity C-reactive protein, ICAS intracranial atherosclerosis, TG triglyceride, HDL high-density lipoprotein

^aThese variables were standardized by division by the standard deviation