Table 1.
KEGG pathways enriched with a significant number of genes involved in CP
| KEGG pathway | CP genes in pathway |
|---|---|
| Pathways in cancer | DVL3;ERBB2;FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;GSTP1;ARNT;LEF1;PDGFRA;PTCH1;RARA;BMP2;BMP4;TGFA;TGFB1;TGFB3;WNT5A;WNT11;WNT10A;AXIN2;FGF18;WNT3A;FGF19;CDH1 |
| Breast cancer | DVL3;ERBB2;FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;JAG2;LEF1;WNT5A;WNT11;WNT10A;AXIN2;FGF18;WNT3A;FGF19 |
| Melanoma | FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;PDGFRA;FGF18;FGF19;CDH1 |
| Hippo signaling pathway | DVL3;FGF1;GDF6;LEF1;BMP2;BMP4;BMP7;TGFB1;TGFB3;WNT5A;WNT11;WNT10A;AXIN2;WNT3A;CDH1 |
| Basal cell carcinoma | DVL3;LEF1;PTCH1;BMP2;BMP4;WNT5A;WNT11;WNT10A;AXIN2;WNT3A |
| Signaling pathways regulating pluripotency of stem cells | DVL3;FGF2;FGFR1;FGFR3;FGFR2;JARID2;PAX6;BMP2;BMP4;WNT5A;WNT11;WNT10A;AXIN2;WNT3A |
| Rap1 signaling pathway | FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;PDGFRA;FGF18;FGF19;CDH1 |
| Regulation of actin cytoskeleton | FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;MYH9;PDGFRA;FGF18;FGF19 |
| MAPK signaling pathway | FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;PDGFRA;TGFB1;TGFB3;FGF18;FGF19 |
| Ras signaling pathway | FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;TBK1;PDGFRA;FGF18;FGF19 |
| Chemical carcinogenesis | NAT2;ADH1C;CYP1A1;CYP1B1;GSTP1;GSTT1;ARNT;UGT1A7;NAT1 |
| One carbon pool by folate | ALDH1L1;DHFR;MTHFD1;MTHFR;MTR |
| PI3K-Akt signaling pathway | COL2A1;FGF1;FGF2;FGF3;FGF4;FGF7;FGF8;FGF9;FGF10;FGFR1;FGFR3;FGFR2;NOS3;PDGFRA;FGF18;FGF19 |
| TGF-beta signaling pathway | GDF6;BMP2;BMP4;BMP7;TGFB1;TGFB3;NOG |
| Prostate cancer | ERBB2;FGFR1;FGFR2;GSTP1;LEF1;PDGFRA;TGFA |
| Cysteine and methionine metabolism | AHCYL2;BHMT2;MTR;BHMT;CBS |
| Proteoglycans in cancer | ERBB2;FGF2;FGFR1;PTCH1;SDC2;TGFB1;WNT5A;WNT11;WNT10A;WNT3A |
| Metabolism of xenobiotics by cytochrome P450 | ADH1C;CYP1A1;CYP1B1;GSTP1;GSTT1;UGT1A7 |
| Adherens junction | ERBB2;FGFR1;LEF1;NECTIN1;NECTIN2;CDH1 |
| EGFR tyrosine kinase inhibitor resistance | ERBB2;FGF2;FGFR3;FGFR2;PDGFRA;TGFA |
| MicroRNAs in cancer | CYP1B1;ERBB2;FGFR3;PDGFRA;ABCB1;TPM1;TP63;WNT3A |
| Caffeine metabolism | NAT2;NAT1 |
| Tryptophan metabolism | TPH2;CYP1A1;CYP1B1;DDC |
| Central carbon metabolism in cancer | ERBB2;FGFR1;FGFR3;FGFR2;PDGFRA |
| Melanogenesis | DVL3;LEF1;WNT5A;WNT11;WNT10A;WNT3A |
| Arginine biosynthesis | ASL;ASS1;NOS3 |
| Wnt signaling pathway | DVL3;LEF1;WNT5A;WNT11;WNT10A;AXIN2;WNT3A |
| Biosynthesis of amino acids | ASL;ASS1;MTR;PAH;CBS |