Table 3.
Unadjusted neurosteroid concentrations (pg/g) in the medial orbitofrontal cortex among males.
| N | Mean | SD | Min | Q1 | Median | Q3 | Max | p valuea | |
|---|---|---|---|---|---|---|---|---|---|
| Pregnenolone | |||||||||
| Control | 19 | 14,824.0 | 27,356.3 | 912.4 | 3,650.3 | 6,678.0 | 9,305.8 | 114,766.7 | |
| PTSD | 12 | 15,246.3 | 18,440.3 | 2,520.2 | 2,957.8 | 8,714.4 | 17,235.6 | 66,197.5 | |
| Overall | 31 | 14,987.4 | 23,953.0 | 912.4 | 3,271.7 | 7,026.4 | 13,777.4 | 114,766.7 | 0.516 |
| Allopregnanolone | |||||||||
| Control | 19 | 208.1 | 280.2 | 72.0 | 99.0 | 105.5 | 166.6 | 1,302.3 | |
| PTSD | 12 | 125.2 | 120.0 | 37.6 | 63.8 | 90.2 | 113.4 | 479.9 | |
| Overall | 31 | 176.0 | 232.6 | 37.6 | 90.9 | 101.4 | 161.8 | 1,302.3 | 0.032 * |
| Pregnanolone | |||||||||
| Control | 19 | 19.3 | 16.1 | 1.9 | 10.1 | 12.6 | 27.1 | 69.8 | |
| PTSD | 12 | 14.3 | 11.4 | 0.0 | 5.1 | 12.7 | 18.6 | 39.7 | |
| Overall | 31 | 17.4 | 14.5 | 0.0 | 7.8 | 12.6 | 23.0 | 69.8 | 0.465 |
| Epiallopregnanolone | |||||||||
| Control | 19 | 175.8 | 152.5 | 79.8 | 92.9 | 108.5 | 171.2 | 624.9 | |
| PTSD | 12 | 133.0 | 121.9 | 37.4 | 71.6 | 107.8 | 128.0 | 496.7 | |
| Overall | 31 | 159.3 | 140.9 | 37.4 | 91.8 | 108.5 | 165.2 | 624.9 | 0.44 |
| Epipregnanolone | |||||||||
| Control | 19 | 35.9 | 32.8 | 5.5 | 12.0 | 30.9 | 48.2 | 145.2 | |
| PTSD | 12 | 20.9 | 11.9 | 7.3 | 12.3 | 19.2 | 26.5 | 46.2 | |
| Overall | 31 | 30.1 | 27.4 | 5.5 | 12.0 | 23.0 | 40.2 | 145.2 | 0.23 |
| THDOC | |||||||||
| Control | 19 | 43.1 | 50.5 | 2.9 | 8.8 | 20.8 | 53.8 | 195.3 | |
| PTSD | 12 | 41.8 | 51.2 | 0.0 | 10.7 | 22.7 | 48.3 | 173.7 | |
| Overall | 31 | 42.6 | 49.9 | 0.0 | 8.8 | 20.8 | 50.7 | 195.3 | 0.84 |
| Androsterone | |||||||||
| Control | 19 | 258.6 | 183.5 | 100.4 | 156.1 | 203.5 | 290.3 | 930.5 | |
| PTSD | 12 | 189.4 | 106.9 | 70.7 | 140.2 | 158.5 | 202.8 | 472.0 | |
| Overall | 31 | 231.8 | 159.9 | 70.7 | 149.9 | 191.5 | 259.2 | 930.5 | 0.081 |
SD: standard deviation; Min: minimum; Q1: quartile 1; Q3: quartile 3; Max: maximum; PTSD: post-traumatic stress disorder; THDOC: tetrahydrodeoxycorticosterone.
a
Statistical test based on Wilcoxon rank-sum test.
*
p < 0.05. Significant p-values are bolded.