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. 2019 Jun 25;10:665. doi: 10.3389/fphys.2019.00665

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Copyright © 2019 Wu, Tang, Ni, Xu, Fang, Xu, Ma, Yang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The muscle atrophy was induced by IL6 infusion in TA muscles of rats. After TA muscles of rats had been injected with saline vehicle or saline vehicle plus IL6 for 14 days, the TA muscles were harvested to undergo laminin staining analysis. Different muscle samples were harvested from rats receiving saline treatment (Ctrl, serving as normal control) and rats receiving IL6 infusion (IL6). (A) TA muscles of rats were stained for laminin after 14 d of saline or IL6 infusion. (B) Mean ± SEM of CSA in TA fibers from each group of rats (^∗∗P < 0.01 for IL6-infused versus PBS-infused rats). (C) Frequency distribution of CSA in TA muscles of PBS or IL6-infused rats.