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. 2019 Jun 25;10:665. doi: 10.3389/fphys.2019.00665

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Copyright © 2019 Wu, Tang, Ni, Xu, Fang, Xu, Ma, Yang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The STAT3/SOCS3 pathway and ubiquitin-proteasome system were induced by IL6 infusion for 14 days in TA muscles of rats. After TA muscles of rats had been injected with saline vehicle or saline vehicle plus IL6 for 14 days, the TA muscles were harvested to undergo Western blotting analysis. Different muscle samples were harvested from rats receiving saline treatment (Ctrl, serving as normal control) and rats receiving IL6 infusion (IL6). Representative Western blot images were shown for STAT3 phosphorylated at Tyr705 (P-STAT3) (A), SOCS3, MuRF-1, and atrogin-1 (C). Histograms comparing p-STAT3 (B), SOCS3, MuRF-1, and atrogin-1 (D) levels among different muscle samples (n = 6). Results are the means ± SEMs. ^∗∗p < 0.01 versus Ctrl.