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. 2019 Jun 25;10:665. doi: 10.3389/fphys.2019.00665

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Copyright © 2019 Wu, Tang, Ni, Xu, Fang, Xu, Ma, Yang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The muscle atrophy induced by denervation is significantly suppressed in Sal-infused and anti-IL6-infused rats. After denervation, TA muscles of rats had been injected with saline vehicle plus salidroside (Den+Sal), saline vehicle plus anti-IL6 (Den+anti-IL6) or saline vehicle only (Den) for 14 days. After sham operation, TA muscles of rats had been injected with saline vehicle (Ctrl) for 14 days. Then, the TA muscles were harvested to undergo laminin staining analysis. (A) TA muscles of rats were stained for laminin after 14 d of saline vehicle, salidroside or anti-IL6 infusion. (B) The wet weight ratio of TA muscles of rats was examined. (C) Mean ± SEM of CSA in TA fibers from each group. (D) Frequency distribution of CSA in fibers of TA muscles from saline vehicle, salidroside or anti-IL6-infused rats. (E) The content of IL6 in TA muscles from saline vehicle or salidroside (^∗P < 0.05, ^∗∗P < 0.01).