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. 2019 Jun 25;10:665. doi: 10.3389/fphys.2019.00665

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Copyright © 2019 Wu, Tang, Ni, Xu, Fang, Xu, Ma, Yang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Salidroside suppressing p-STAT3 and SOCS3 expression might be through inhibiting IL6 in muscle. (A,C) Representative blots of p-STAT3 and SOCS3 in TA muscles treated with salidroside or anti-IL6. Salidroside decreased the expression of p-STAT3 and SOCS3 in the denervated muscles. (B,D) Relative expression of p-STAT3 and SOCS3 in TA muscles treated with salidroside or anti-IL6. Anti-IL6 decreased the expression of p-STAT3 and SOCS3 in the denervated muscles (n = 6 rats in each group). ^∗∗p < 0.01 versus Den. ^#p < 0.05 and ^##p < 0.01 versus Ctrl.