Table 1.
The studies of the association between the TL and obesity
| Author (year) | Participant | LTL measurement method | Obesity marker | Association |
|---|---|---|---|---|
| Lee et al. (2011)8 | 8–80 yr, Adults (n=309, 52% women) | qPCR | BMI, WC, HipC, %fat, VAT | Negative |
| Njajou et al. (2012)9 | 70–79 yr, Adults (n=2,721, 51.6% women) | qPCR | %Body fat, SAT | Negative |
| Bekaert et al. (2007)11 | 35–55 yr, Adults (n=2,509, 51.5% women) | Southern blot for WBC TRF | Body weight, BMI, WC | No |
| Diaz et al. (2010)12 | 40–64 yr, Adults (n=317, 54.9% women) | qPCR | BMI, VAT | No |
| Valdes et al. (2005)15 | 18–76 yr, Women (n=1,122) | Southern blot for WBC TRF | BMI | Negative |
| Cherkas et al. (2008)16 | 18–81 yr, Twins (n=2,401, 89.6% women) | Southern blot for WBC TRF | BMI | Negative |
| Nordfjäll et al. (2008)41 | 26–75 yr, Adults (n=989, 48.0% women) | qPCR | BMI, body weight, WC, HipC in women | Negative |
| Moreno-Navarrete et al. (2010)42 | 31–61 yr, Obese women (n=21, waist 110–147cm) | qPCR in adipocyte | WC, adipocyte size with TL of adipocytes | Negative |
| Monickaraj et al. (2012)43 | 34–56 yr, Obese, diabetic, and obese-diabetic subjects (n=59, 57.6% women) | qPCR in SAT | BMI | Negative |
| Jones et al. (2014)44 | >35 yr, Obese, diabetic, and obese-diabetic subjects (n=61) | qPCR in SAT & VAT | Adipose hypertrophy | Negative |
| Kim et al. (2013)45 | >60 yr, Women (n=129) | qPCR | BMI, WC | Negative |
| Cui et al. (2013)46 | 40–70 yr, Women (n=2,912) | qPCR | Body weight, WC, HipC, BMI, WHtR WHR, height | Negative or no |
| Al-Attas et al. (2010)47 | 5–12 yr, Children (n=148, 53.4% girls) | qPCR | WC in girls | Negative |
| Fitzpatrick et al. (2007)48 | 74.2±5.2 yr (Mean±SD), adults (n=419) | Southern blot for WBC TRF | Body size, age ≤73 yr | Negative or no |
| Gardner et al. (2005)49 | 21–43.5 yr, Adults (n=70, 57.1% women) | Southern blot for WBC TRF | BMI | Negative |
| Farzaneh-Far et al. (2010)50 | 55–78 yr, CAD (n=608, 17.9% women) | qPCR | BMI | No |
| Bischoff et al. (2006)51 | 79–101 yr, Elderly twins (n=812, 67.9% women) | qPCR | Obesity | No |
| Oliveira et al. (2018)52 | 65–74 yr, Women (n=83) | qPCR | Body weight, BMI, WC | No |
TL, telomere length; LTL, leukocyte telomere length; qPCR, quantitative polymerase chain reaction; BMI, body mass index; WC, waist circumference; HipC, hip circumference; VAT, visceral adipose tissue; SAT, subcutaneous adipose tissue; WBC, white blood cell; TRF, terminal restriction fragment; WHtR, waist to height ratio; WHR, waist to hip ratio; SD, standard deviation; CAD, coronary artery disease.