Table 4.
Summary of the association between the TL and cardiorespiratory fitness
| Author (year) | Subject | LTL measurement method | Intervention or factor | Association |
|---|---|---|---|---|
| LaRocca et al. (2010)18 | 18–32 yr vs. 55–72 yr (n=57, 59.6% women) | Southern blot for WBC TRF | Maximal Ex test (VO2max) | LTL was positively associated with VO2max in older adults |
| Edwards and Loprinzi (2016)97 | >20 yr, Adults (n=1,868, 49.2% women) | qPCR | Submaximal treadmill test (CRF) | No association |
| Mathur et al. (2013)107 | 15 yr, Boys (n=32) | Lymphocyte TL | Maximal Ex test (VO2max) | No association |
| Mason et al. (2013)110 | 50–75 yr, Postmenopausal women (n=439) | qPCR | Maximal Ex test (VO2max) | LTL was positively associated with VO2max |
| Krauss et al. (2011)111 | 944 Adults with CVD (20% women) | qPCR | Maximal Ex test (CRF) | High CRF (>7 METs) had two-fold longer LTL vs. low CRF |
| Soares-Miranda et al. (2015)112 | 73.5 yr, Adults (n=582, 62% women) | Southern blot for WBC TRF | 15-ft walk (sec), grip strength (kg), chair stands (sec) | A better chair test performance in longer LTL Changes chair time was associated with changes in LTL |
TL, telomere length; LTL, leukocyte telomere length; WBC, white blood cell; TRF, terminal restriction fragment; Ex, exercise; VO2max, maximum oxygen consumption; qPCR, quantitative polymerase chain reaction; CRF, cardiorespiratory fitness; CVD, cardiovascular disease; METs, metabolic equivalent of task.