Table 1.
Clinical and biochemical characteristics of patients stratified by presence of DPN
| Variable | DPN (−) (n=36) | DPN (+) (n=29) | P |
|---|---|---|---|
| Male sex | 25 (69.4) | 18 (62.1) | 0.603 |
|
| |||
| Age (yr) | 47.3±5.6 | 47.9±8.0 | 0.730 |
|
| |||
| Height (cm) | 168.2±9.2 | 164.2±9.4 | 0.092 |
|
| |||
| Body weight (kg) | 68.7±13.5 | 71.4±14.7 | 0.438 |
|
| |||
| BMI (kg/m2) | 24.1±3.2 | 26.5±4.3 | 0.011 |
|
| |||
| SBP (mmHg) | 128.8±10.6 | 134.8±14.8 | 0.063 |
|
| |||
| DBP (mmHg) | 77.1±7.7 | 79.3±9.7 | 0.304 |
|
| |||
| Diabetes duration (yr) | 7.3±5.0 | 10.0±8.3 | 0.144 |
|
| |||
| Glucose (mg/dL) | 139.3±29.6 | 156.0±57.9 | 0.165 |
|
| |||
| HbA1c (%) | 7.2±1.2 | 7.8±1.8 | 0.111 |
|
| |||
| Cholesterol (mg/dL) | 169.0±42.1 | 160.8±52.3 | 0.486 |
|
| |||
| Triglyceride (mg/dL) | 160.6±156.9 | 208.6±248.0 | 0.417 |
|
| |||
| HDL cholesterol (mg/dL) | 50.4±12.2 | 47.0±16.7 | 0.347 |
|
| |||
| LDL cholesterol (mg/dL) | 95.3±25.8 | 88.5±32.9 | 0.352 |
|
| |||
| BUN (mg/dL) | 15.7±3.4 | 15.8±4.8 | 0.945 |
|
| |||
| Creatinine (mg/dL) | 0.7±0.2 | 0.8±0.2 | 0.288 |
|
| |||
| eGFR (mL/min/1.73 m2) | 108.7±23.0 | 100.5±24.2 | 0.168 |
|
| |||
| AST (IU/L) | 26.9±15.3 | 35.1±19.2 | 0.004 |
|
| |||
| ALT (IU/L) | 27.8±19.5 | 38.4±22.3 | 0.045 |
|
| |||
| Insulin | 6.5±3.0 | 8.9±5.0 | 0.093 |
|
| |||
| HOMA-IR | 2.3±1.2 | 3.4±2.1 | 0.024 |
|
| |||
| MNSI-Q (score) | 2.0±1.7 | 3.6±2.8 | 0.021 |
|
| |||
| MNSI-PE (score) | 1.3±0.7 | 3.4±1.0 | <0.001 |
|
| |||
| Smoking status | 0.074 | ||
| Never smoker | 10 (27.8) | 16 (55.2) | |
| Ex-smoker | 12 (33.3) | 5 (17.2) | |
| Current smoker | 14 (38.9) | 8 (29.6) | |
|
| |||
| Alcohol | 23 (63.9) | 15 (51.7) | 0.448 |
|
| |||
| Hypertension | 22 (61.1) | 21 (72.4) | 0.432 |
|
| |||
| Dyslipidemia | 21 (58.3) | 19 (65.5) | 0.614 |
|
| |||
| Oral antidiabetic medication | 32 (88.9) | 27 (93.1) | 0.684 |
|
| |||
| Insulin therapy | 5 (13.9) | 8 (27.6) | 0.218 |
Values are presented as number (%) or mean±standard deviation.
DPN, diabetic peripheral neuropathy; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HbA1c, glycosylated hemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; AST, aspartate aminotransferase; ALT, alanine aminotransferase; HOMA-IR, homeostatic model assessment for insulin resistance; MNSI-Q, Michigan Neuropathy Screening Instrument-questionnaire; MNSI-PE, MNSI-physical examination.