Figure 8.

Model of the Syt10 functional role in neuroprotection. A, Identification of Syt10 as a new downstream target of NPAS4 during normal synaptic activity. Synaptic activity results in an increase of nuclear calcium (black arrow), leading to increased expression of AID genes (black arrow) resulting in an upregulation the NPAS4 target gene Syt10 (black arrow) eventually protecting neurons from cell death by a yet unknown secreted factor. B, Here, we claim a new function for Syt10 in neuroprotection following pathophysiologic synaptic activity. Syt10 plays an essential role in neuroprotection following pathophysiologic synaptic activity as only Syt10 WT but not Syt10 KO neurons can be rescued by NPAS4 from KA-induced cell death.