Table 3.

Metabolomic predictors selected by SCAD-penalized linear regression for four year outcomes.

Outcome	Metabolite	Time of measurement	Direction of association
HAZ at 4 years	Conjugated:unconjugated bile acid ratio	9 months	(−)
	C10	9 months	(−)
	C14:1-OH	9 months	(−)
	Total SM[OH]	9 months	(+)
	C2	36 months	(+)
	Threonine	36 months	(+)
	PC ae C44:6	36 months	(+)
∆HAZ from enrollment to 4 years	TUDCA	9 months	(−)
	Total conjugated bile acids	9 months	(−)
	Glutamic Acid	9 months	(−)
	PC aa C28:1	9 months	(+)
	PC aa C34:2	9 months	(+)
	PC aa C34:3	9 months	(−)
	Total SM[OH]	9 months	(+)
	C2	36 months	(+)
	Glycine	36 months	(−)
	Leucine	36 months	(+)
	PC aa C28:1	36 months	(+)
	PC aa C38:5	36 months	(+)
	PC ae C44:4	36 months	(+)
WPPSI-III full scale IQ score at 4 Years	Threonine	9 months	(+)
	Kynurenine	9 months	(−)
	Threonine	36 months	(+)
	PC aa C32:3	36 months	(+)
	PC ae C30:2	36 months	(+)
	PC ae C34:3	36 months	(+)