Figure 6.
KCC2 and GABAAR expression is modulated either by vestibular lesion and BDNF infusion. A, Confocal analysis of neurons immunostained with either the KCC2 or GABAAR located in the contralateral (intact) and ipsilateral (lesioned) lateral VN of sham or UVN animals infused with NaCl, BDNF, or K252a from days 0–3 after UVN. Scale bar, 20 μm. n = 4 animals per group. B, Histograms showing the effects of NaCl, BDNF, or K252a continuous infusion on KCC2 or GABAAR immunostainings in both intact and lesioned lateral VN 3 d after UVN. SEMs are shown as vertical lines. Data from both sides of sham group were pooled for direct comparison with the subgroups of vestibular deafferented cats. *Significant differences between groups of animals or between lesioned versus intact side in the same animal in the UVN-NaCl, UVN-BDNF, and UVN-K252a groups. *p < 0.005; **p < 0.001; ***p < 0.0001.