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. 2019 Jun 25;13:672. doi: 10.3389/fnins.2019.00672

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Copyright © 2019 Zhou, Li, Yang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quercetin increased the frequency and amplitude of GABAergic mIPSCs in OFF-type RGCs. (A) Representative traces showing the effect of 10 μM quercetin on mIPSCs. Vertical scale bar, 20 pA; horizontal scale bar, 1 min. (B) Recordings from a large-scale representative experiment under control conditions (B1), during quercetin treatment (B2), and during recovery (B3). (C,D) Cumulative frequency and amplitude distributions of GABAergic mIPSCs in a representative neuron under control conditions and during quercetin treatment showing that quercetin caused the cumulative frequency curve to shift significantly to the left and the cumulative amplitude curve to shift significantly to the right. (E,F) Summarized data on the frequency (E) and amplitude (F) of GABAergic mIPSCs (n = 9; from six slices). ^∗∗p < 0.01 and ^∗∗∗p < 0.001 compared with the control conditions; paired Student’s t-test.