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. 2019 Jun 25;13:672. doi: 10.3389/fnins.2019.00672

FIGURE 5.

FIGURE 5

Quercetin significantly increased the frequency, but not the amplitude, of mIPSCs in ON-type RGCs. (A) Representative recordings showing that quercetin increased the frequency but not amplitude of mIPSCs. (A, top) control condition; (A, middle) during quercetin treatment; (A, bottom) recovery period. Vertical bar, 10 pA; horizontal bar, 1 s. (B,C) Cumulative interevent interval and amplitude distributions of mIPSCs in a representative neuron during a control recording and after quercetin application. Quercetin significantly shifted the distribution of interevent intervals to the left (B) but did not shift the distribution of mIPSC amplitudes (C). The quercetin-induced changes in the distribution of interevent intervals were statistically significant (n = 11). ∗∗p < 0.01, Kolmogorov–Smirnov test. (D,E) Summarized data for the frequency (D) and amplitude (E) of mIPSCs (frequency: n = 13; amplitude: n = 9). ∗∗p < 0.01, paired Student’s t-test.