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. 2019 Jun 25;13:672. doi: 10.3389/fnins.2019.00672

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Copyright © 2019 Zhou, Li, Yang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quercetin hyperpolarized RGCs and decreased the firing rate. (A,B) Top trace: responses to a –200 pA current step in OFF-type RGCs (A) and ON-type RGCs (B). Negative current injection led to rebound burst firing in OFF-type RGCs but not in ON-type RGCs. Vertical bar, 20 mV; horizontal bar, 50 ms. (C) Current clamp recording of a representative RGC. Note that quercetin caused hyperpolarization and decreased the firing rate. Recordings under control conditions (C1), during application of quercetin (C2), and during washout (C3) are shown on an expanded time scale. (D) Bar graph summarizing the changes in MP. Quercetin can hyperpolarize MP. MP, membrane potential. ^∗p < 0.05, paired Student’s t-test.