Table 1.
Model constants, parameters, and variables with default (resting) values
| Value | Description | |
|---|---|---|
| Constant | ||
| F | 96485.333 C/mol | Faraday's constant |
| R | 8.3144598 (C/V)/(mol K) | Universal gas constant |
| T | 310 K | Absolute temperature |
| Parameter | ||
| C | 20 pF | Membrane capacitance |
| PNa+T | 800 μm3/s | Maximal transient Na+ permeability |
| PNa+L | 2 μm3/s | Leak Na+ permeability |
| PK+D | 400 μm3/s | Maximal delayed rectifier K+ permeability |
| PK+L | 20 μm3/s | Leak K+ permeability |
| PCl−G | 19.5 μm3/s | Maximal voltage-gated Cl− permeability |
| PCl−L | 2.5 μm3/s | Leak Cl− permeability |
| QPump | 54.5 pA | Maximal Na+/K+ pump current |
| UKCl | 1.3 fmol/(s/V) | KCl cotransporter strength |
| [Na+]e | 152 mmw | Extracellular bath Na+ concentration |
| [K+]e | 3 mm | Extracellular bath K+ concentration |
| [Cl−]e | 135 mm | Extracellular bath Cl− concentration |
| LH2O | 2 μm3 (s bar) | Effective membrane water permeability |
| [S]e | 310 mm | Total extracellular solute concentration |
| NiA− | 296 fmol | Intracellular amount of impermeant anions |
| Variable | ||
| V | −65.5 mV | Membrane potential |
| M | 0.013 | Transient Na+ activation gate |
| H | 0.987 | Transient Na+ inactivation gate |
| N | 0.003 | Delayed rectifier K+ activation gate |
| [Na+]i | 10 mm | Intracellular Na+ concentration |
| [K+]i | 145 mm | Intracellular K+ concentration |
| [Cl−]i | 7 mm | Intracellular Cl− concentration |
| W | 2000 μm3 | Intracellular volume |