Figure 9.

Treatment with the F-actin stabilizer phallacidin and the Src kinase inhibitor PP2 rescued the functional phenotype seen in ChAc neurons (n = 33–98). Treatment of differentiating cells with 100 nm phallacidin (A–C) or 10 μm PP2 (D–F) 72 h before analysis decreased the frequency and amplitudes of mPSCs to the level of control cells (n = 8–101). C, F, AP amplitudes were reduced significantly by phallacidin and PP2 as well. All data are given as means ± SEM of individual cell lines and as averaged values (p < 0.05, Mann–Whitney test).