Figure 3.

Application of the β2-nAChR antagonist DHβE increases Up state duration and occurrence, and subsequent addition of the α7-nAChRs antagonist MLA causes further prolongation of Up state duration. A, B, LFP traces of Up state activity at higher and lower temporal resolution, respectively, and (C) intracellular recordings obtained in control conditions in the absence of drugs (top), in the presence of 3 μm DHβE (middle), and in the presence of 3 μm DHβE + 10 nm MLA (bottom). LFP traces in A and B are from WT (left) and β2^−/− (right) mice. Traces from intracellular recordings are truncated at −25 mV.