Figure 5.

Dose-dependent effect of nicotine on Up state activity in WT mice. LFP traces of Up state activity at higher (left) and lower (right) temporal resolution in the presence of 10 μm (A) or 300 nm (B) nicotine. C, High concentration of nicotine (10 μm) is ineffective in producing significant changes in Up state duration or occurrence. D, In contrast, a low concentration of nicotine (300 nm) reduces both Up state duration and occurrence. Values in C and D are normalized to controls in the absence of 10 μm and 300 nm nicotine, respectively, while insets demonstrate non-normalized values (mean ± SEM, paired t tests, **p < 0.01).