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. 2015 Aug 12;35(32):11196–11208. doi: 10.1523/JNEUROSCI.5222-14.2015

Figure 8.

Figure 8.

The effects of β2-nAChRs on Up state activity are at least partly mediated through GABAB receptors. A, B, Application of the GABAB receptor antagonist CGP55845 leads to increased Up state duration and occurrence (mean ± SEM, data normalized to control values obtained in the absence of CGP55845). C, D, Subsequent application of DHβE (in the presence of CGP55845) fails to produce the expected changes in Up state activity (mean ± SEM, data normalized to values in the presence of CGP55845 before the addition of DHβE). E, F, Further application of MLA leads to the expected increase in Up state duration (mean ± SEM, data normalized to values obtained in the presence of both CGP55845 and DHβE before the addition of MLA). G, H, Non-normalized values of Up state duration and occurrence, respectively, before and after the addition of CGP55845, DHβE, and MLA (mean ± SEM). These results are obtained in adult WT animals (one-way repeated-measures ANOVA, with pairwise comparisons post hoc tests, *p < 0.05, **p < 0.01, and ***p < 0.001).