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. 2015 Jul 1;35(26):9622–9631. doi: 10.1523/JNEUROSCI.3973-14.2015

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Copyright © 2015 the authors 0270-6474/15/359622-10$15.00/0

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Figure 5. — NPY inhibits excitatory transmission in human epileptic hippocampus via Y2 receptors. Representative traces of paired-pulse stimulation-induced fEPSPs in CA1 stratum radiatum (A) or MPP-dentate granule cell synapses (D) before (black) and after (blue) NPY application in presence of the Y2 receptor antagonist BIIE0246. Normalized slopes (B) and PPR (C) of fEPSPs evoked by Schaffer collateral stimulation in CA1 area, showing absence of NPY effect in presence of BIIE0246. Calibrations: A, 20 ms and 0.1 mV; D, 20 ms and 0.4 mV.