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. 2015 Jun 17;35(24):9007–9016. doi: 10.1523/JNEUROSCI.4024-14.2015

Figure 5.

Figure 5.

Inhibition of wild-type FKBP51 by SAFit2 induces anxiolytic behavior in a time-dependent manner. A–D, Mice tested 1 h after peripheral SAFit2 injection (i.p.) shown no alterations in anxiety-related behavior in the EPM or DaLi. E, Mice show a significant increase in the open arm time of the EPM 16 h after peripheral administration of SAFit2. F, G, SAFit2 leads to significantly increased entries to the lit compartment and significantly more time spent in the lit compartment of the DaLi 16 h after peripheral application. H, I, Mice treated with SAFit2 showed a significantly decreased latency to enter and a significantly increased distance traveled in the lit compartment of the DaLi 16 h after the intraperitoneal injection; n = 10–11. J, Schematic representation of the cannula placement. X represents the tip of the guiding cannula. K, mice treated with SAFit2 via BLA microinjections show a significant increase in the number of lit compartment entries in the DaLi. L, M, SAFit2 BLA microinjections lead toward a trend to increased time spent in the lit compartment and a significantly decreased latency to enter the lit compartment of the DaLi; n = 14, #p < 0.05. Data are expressed as mean + SEM.