Figure 1.

Aβ diminishes GABAergic synaptic transmission. A, IPSC amplitude time course (■) and sample IPSCs (bottom) recorded in whole-cell voltage-clamp mode at 0 mV. Aβ (1 μm) was bath applied as indicated by the horizontal bar. There is pronounced reduction of the IPSCs after the peptide was added. The glutamate receptor antagonists DNQX (20 μm) and APV (50 μm) were present throughout the experiment. B, Similar experiment to A with the reversed control peptide of Aβ. The control peptide had no significant effect on the IPSCs. C, Summary histograms (mean ± SEM) of all experiments with the active (n = 14) and control (n = 5) sequence of Aβ indicating a statistically significant difference. **p < 0.01 (unpaired t test).