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. 2015 Apr 15;35(15):6117–6130. doi: 10.1523/JNEUROSCI.4145-14.2015

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Copyright © 2015 the authors 0270-6474/15/356117-14$15.00/0

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Figure 6. — Characterization of the synaptic drive received by locomotor-driven thoracic motoneurons. A, Time courses of the overall membrane potential depolarization recorded from a T7 motoneuron from the onset to the end of a locomotor episode induced by restricted applications of NMA/5-HT compared with the lumbar cord under control conditions (A1), and during thoracic bath application of DNQX (5 μm) alone (A2) or combined with AP5 (5 μm; A3). Note the decreased amplitude of the slow depolarization in the presence of DNQX and DNQX/AP5. B, Sequences of locomotor-like activity extracted from the episodes presented in A, which show that the membrane potential oscillations are phase-locked to the locomotor activity. The bottom panels illustrate the mean cycle (repeated 4 times) obtained using the left L2 at the thoracic level under control conditions as the reference, or in the presence of DNQX or DNQX/AP5. C, Representative traces of a thoracic motoneuron (T10) recorded during NMA/5-HT-induced locomotion under control conditions (C1) and in the presence of strychnine (2 μm), DNQX (5 μm), and AP5 (5 μm; C2) applied to the thoracic segments. r, Right; l, left; T, thoracic; L, lumbar.