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. 2015 Apr 15;35(15):6209–6220. doi: 10.1523/JNEUROSCI.4624-14.2015

Figure 6.

Figure 6.

Region-specific ablation or reactivation of striatal MeCP2 alters local dopamine content and locomotor activity. A–F, Total distance traveled of mice at 4–5 weeks of age was measured in an open field before (A, D) or 14 d after (B, E) AAV injection, followed by dopamine measurement with HPLC (C, F). The Flox mice with AAV injection into ST-r [Flox/Cre (+)] traveled shorter distance (B) and contained lower dopamine content in the ST-r (C) compared with AAV-injected WT mice [WT/Cre(+)] and saline-injected Flox mice [Flox/Cre(−)]. Upon AAV injection to ST-c (D–F), Flox mice exhibit reduced local dopamine content in the ST-c (F) but normal open-field activity (E). G–I, Selective reactivation of MeCP2 in the ST-r of STOP mice restores both locomotor activity (H) and local dopamine content in the ST-r (I) 14 d after AAV injection. Locomotor activity of STOP mice before surgery (4–5 weeks old) was not significantly different from WT controls (G); *p < 0.05, **p < 0.01, ***p < 0.001, compared with indicated control mice by one-way AVOVA followed by Bonferroni post hoc test.