FBXO41−/− mice show reduced cerebellar size and abnormal architecture with age. A–C, Panels depict H&E-stained 5 μm sagittal brain sections of FBXO41+/+ and FBXO41−/− mice at P12, P16, and P30. Scale bars, 1000 μm. D–F, Graphs representing quantifications of relative sizes of the cortex, hippocampus, and the cerebellum, respectively, as observed in the FBXO41+/+ and −/− mice at the indicated ages (P12, P16, and P30). Areas are represented as percentage. Three wild-type and three knock-out littermate pairs were analyzed (two-way ANOVA, **p < 0.01, *p < 0.05, mean + SEM).