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. 2015 Apr 22;35(16):6401–6412. doi: 10.1523/JNEUROSCI.4208-14.2015

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Copyright © 2015 the authors 0270-6474/15/356401-12$15.00/0

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Figure 6. — PLC is involved in mGluR-LTD induced by PP-LFS-LTD, but not in DHPG-LTD. EPSC amplitudes were normalized to the pre-DHPG or PP-LFS baseline values and were averaged. A, DHPG application induced a persistent depression of EPSC amplitude (black). Preincubation of slices in U73122 did not affect the magnitude of DHPG-LTD (red). The inset shows representative EPSCs during the baseline period (dark) and 40 min after (light) DHPG application in each condition. B, PP-LFS induced a similar magnitude of LTD compared with DHPG-LTD (black). PP-LFS-LTD was significantly blocked by U73122 (red). C, Pharmacological blockade of mGluR5 by MPEP almost completely blocked PP-LFS-LTD (red). D, PP-LFS-LTD was blocked by nimodipine (red). Insets (B–D) represent EPSCs during the baseline period (dark) and 35 min after (light) PP-LFS in each condition. Ea, Representative EPSCs elicited by paired-pulse stimulation (50 ms interval) during baseline (black, left) and after DHPG application or PP-LFS (gray, middle). Superimposed traces are shown in right panels. Scale bar, 50 ms (horizontal) and 100 pA (vertical). Eb, Bar graphs summarize paired-pulse ratio (PPR) changes in each group. n.s p > 0.05. Error bars represent SEM.