Table 2.

Effect of intra-DRN baclofen on aggressive and nonaggressive behaviors in 5-HTT−GABA_B1^−/− (cKO) mice

	aCSF	Baclofen 0.06 nmol	Baclofen 0.3 nmol
Attack bites
WT	20.5 ± 2.9	32.9 ± 3.6	43.9 ± 7.3*
cKO	15.7 ± 2.7	41.2 ± 7.9*	34.5 ± 6.5*
Sideways threats (s)
WT	12.0 ± 1.8	23.8 ± 3.5*	24.8 ± 5.8*
cKO	8.8 ± 2.0	28.8 ± 6.5*	21.6 ± 5.8
Tail rattles (s)
WT	18.0 ± 3.7	33.1 ± 7.3	37.6 ± 9.0
cKO	11.8 ± 3.4	27.2 ± 6.6*	32.9 ± 7.4*
Pursuits (s)
WT	6.7 ± 2.6	10.3 ± 2.9	26.6 ± 9.7*
cKO	4.7 ± 2.3	15.2 ± 5.1	15.9 ± 4.8
Walking (s)
WT	73.5 ± 5.5	74.9 ± 7.8	113.1 ± 19.9
cKO	80.5 ± 5.7	72.0 ± 6.6	125.5 ± 21.9
Rearing (s)
WT	16.3 ± 3.3	11.5 ± 3.3	7.3 ± 2.3
cKO	19.8 ± 3.9	13.1 ± 4.1	9.1 ± 3.0
Self-grooming (s)
WT	29.2 ± 8.7	28.2 ± 4.9	14.1 ± 4.8
cKO	32.2 ± 7.5	23.5 ± 4.7	12.8 ± 3.9*
Social contact (s)
WT	22.0 ± 8.5	15.9 ± 3.9	20.3 ± 7.5
cKO	18.2 ± 4.8	14.3 ± 3.6	20.4 ± 4.8

All values are mean ± SEM;

*p < 0.05 compared with aCSF.