Table 1.

Aβ40 and Aβ42 in blood plasma and cerebral cortex at 16 months

	Females		Males
	Control	ADINKO	Control	ADINKO
Aβ40
Plasma concentration (pg/ml)	769 ± 74	953 ± 37**	808 ± 42	798 ± 84
Total amount in plasma (ng)a	2.1 ± 0.3	3.0 ± 0.2*	2.5 ± 0.1	3.0 ± 0.4
Soluble amount in cortex (ng)b	120 ± 27	51 ± 8*	60 ± 10	28 ± 4*
Plasma/cortex ratio (%)	3.0 ± 1.3	7.1 ± 0.9**	6.3 ± 1.8	12.2 ± 2.2**
Aβ42
Plasma concentration (pg/ml)	389 ± 45	541 ± 23*	488 ± 39	485 ± 40
Total amount in plasma (ng)a	1.1 ± 0.1	1.7 ± 0.1**	1.5 ± 0.1	1.8 ± 0.2
Soluble amount in cortex (ng)b	550 ± 47	382 ± 33*	443 ± 54	267 ± 32*
Plasma/cortex ratio (%)	0.21 ± 0.04	0.48 ± 0.04**	0.44 ± 0.11	0.77 ± 0.11**

^aAβ plasma pool was determined from concentration and plasma volume (80 μl g⁻¹ of body weight; (Gunji et al., 2002).

^bAmount of soluble Aβ in cortex was calculated from concentration (Fig. 3B) and cortex weight.

*p < 0.05 and

**p < 0.01, ADINKO versus control.

Mean ± SEM, n = 7–12, Mann–Whitney U test.