Table 2.

Morphometry of IGF-1R knock-out neurons^a

	IGF-1RWT/WT	IGF-1RKO/KO	Percentage difference	P
Neuronal soma length (μm)	10.1 ± 0.3b	9.2 ± 0.2b	−9%	0.048
Neuronal soma diameter (μm)	6.0 ± 0.2	5.4 ± 0.3	−10%	Not significant
Neuronal soma volume (μm3)	293 ± 18	219 ± 18	−25%	0.016
Nucleus volume (μm3)	111 ± 11	117 ± 10	−5%	Not significant
Cytoplasm volume (μm3)	176 ± 10	108 ± 16	−39%	0.005
Apical cytoplasm height (μm)	1.69 ± 0.09	1.29 ± 0.08	−24%	0.009
Basal cytoplasm height (μm)	1.30 ± 0.13	1.38 ± 0.11	+6%	Not significant
Primary dendrite length (μm)	34.8 ± 2.2	18.6 ± 2.4	−47%	< 0.001
Primary dendrite thickness (μm)	1.64 ± 0.07	1.24 ± 0.13	−25%	0.022
Distal branch thickness (μm)	0.62 ± 0.03	0.53 ± 0.02	−15%	0.021

^aMeasurements were performed on dentate gyrus granular neurons from NestinCreER^T2+/0;CAG-tdTomato^+/0;IGF-1R^flox/flox mice (IGF-1R^KO/KO) and NestinCreER^T2+/0;CAG-tdTomato^+/0;IGF-1R^WT/WT controls (IGF-1R^WT/WT).

^bMean ± SEM, n = 6 mice per group, Student's t test.