Figure 5.
Biostatistical analysis to identify genes of interest. a, Gene ontology performed on GOrilla software for all genes differentially expressed between activated aOPCs and nonactivated aOPCs. b, Gene ontology for genes differentially expressed in activated aOPCs versus those in the nonactivated aOPC database and in the reported early repair database of caudal cerebellar peduncle (CCP) lesions comparing 14 versus 5 dpl. c, Representation of the 119 genes differentially expressed in both databases. d, Identification of a group of seven interacting genes, using Ariadne Genomics–Pathway Studio. e, qPCR detection of CCL2, CCR2, IL1β, and IL1R1 on activated aOPCs and nonactivated aOPCs. qPCR showing CCL2 and IL1β expression in activated aOPCs (n = 4; Student's t test, ***p < 0.001).