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. 2015 Jan 7;35(1):4–20. doi: 10.1523/JNEUROSCI.0849-14.2015

Figure 9.

Figure 9.

a, b, Ccl2 immunostaining on MS tissues. OPCs (nuclear Olig1 staining) expressing Ccl2 (arrowhead) in an active lesion (a) and active borders of a chronic lesion (b). c, d, Virtually no Ccl2-expressing OPCs in a chronic lesion (c) or NAWM area (d). Scale bar, 50 μm. e, High-magnification image of one OPCs, stained by nuclear Olig1 antibody (red), expressing Ccl2 (green). Scale bar, 10 μm. f, Ratio of the percentage of nuclear Olig1-positive cells expressing Ccl2 in multiple sclerosis lesions, compared to adjacent NAWM of the same size (n = 3–6, depending on the type of lesion; one-way ANOVA and Holm–Sidak multiple-comparisons test, *p < 0.05).