Table 1.
The top 50 genes overexpressed in activated aOPCs compared with nonactivated aOPCs
| ID | Symbol | Gene name | Activated aOPCs/non-activated aOPCs ratio | p value* | q value† |
|---|---|---|---|---|---|
| A_51_P363947 | Cdkn1a | Cyclin-dependent kinase inhibitor 1A (P21) | 176.23 | 1.00E-05 | 0.003 |
| A_55_P1986296 | Tagln2 | Transgelin 2 | 46.53 | 0 | 0.00031 |
| A_51_P330428 | Eif4ebp1 | Eukaryotic translation initiation factor 4E binding protein 1 | 38.11 | 0 | 0.00018 |
| A_51_P519251 | Nupr1 | Nuclear protein 1 | 37.6 | 1.00E-04 | 0.00758 |
| A_55_P1959748 | Asns | Asparagine synthetase | 35.84 | 9.00E-04 | 0.02023 |
| A_66_P106661 | Slc7a1 | Solute carrier family 7 (cationic amino acid transporter, y + system), member 1 | 28.68 | 0 | 0.0019 |
| A_51_P241995 | Col5a3 | Collagen, type V, α3 | 27.97 | 0 | 0.00191 |
| A_55_P1954221 | Emp1 | Epithelial membrane protein 1 | 20.78 | 1.00E-05 | 0.003 |
| A_66_P111562 | Ccnd1 | Cyclin D1 | 20.53 | 5.00E-05 | 0.00567 |
| A_51_P315904 | Gadd45g | Growth arrest and DNA damage-inducible 45 γ | 20.08 | 1.00E-04 | 0.00758 |
| A_51_P392687 | Vim | Vimentin | 18.26 | 0.00021 | 0.01032 |
| A_51_P352968 | Marcks | Myristoylated alanine-rich protein kinase C substrate | 18.06 | 0.00013 | 0.0085 |
| A_51_P390538 | Mpeg1 | Macrophage expressed gene 1 | 17.13 | 0.00058 | 0.01618 |
| A_51_P131408 | Tnfrsf12a | Tumor necrosis factor receptor superfamily, member 12a | 16.75 | 2.00E-05 | 0.00343 |
| A_51_P102789 | C1qc | Complement component 1, q subcomponent, C chain | 15.89 | 0.00032 | 0.01265 |
| A_52_P1197913 | Gadd45b | Growth arrest and DNA damage-inducible 45 β | 15.34 | 0 | 0.0019 |
| A_55_P2033376 | 1810041L15Rik | RIKEN cDNA 1810041L15 gene | 13.55 | 0.00344 | 0.0421 |
| A_51_P110759 | Slc1a1 | Solute carrier family 1 (neuronal/epithelial high-affinity glutamate transporter, system Xag), member 1 | 12.9 | 0.00116 | 0.02318 |
| A_55_P2064547 | Tuba1c | Tubulin, α1C | 12.28 | 0.00035 | 0.01296 |
| A_55_P2068892 | Il6ra | Interleukin 6 receptor, α | 12.03 | 5.00E-05 | 0.00545 |
| A_51_P359636 | Lgals3bp | Lectin, galactoside-binding, soluble, 3 binding protein | 12.01 | 0 | 0.0019 |
| A_55_P2345853 | 3200002M19Rik | RIKEN cDNA 3200002M19 gene | 11.86 | 6.00E-04 | 0.01648 |
| A_55_P2165869 | Cebpb | CCAAT/enhancer binding protein (C/EBP), β | 11.7 | 0.00079 | 0.01914 |
| A_55_P2121608 | Sox4 | SRY-box containing gene 4 | 11.43 | 0 | 0.0019 |
| A_66_P135173 | 9630013A20Rik | RIKEN cDNA 9630013A20 gene | 11.23 | 0.00038 | 0.01363 |
| A_55_P2000439 | Ptprz1 | Protein tyrosine phosphatase, receptor type Z, polypeptide 1 | 11.23 | 0.00382 | 0.04504 |
| A_55_P1971599 | Bcan | Brevican | 11.09 | 0.00013 | 0.00837 |
| A_51_P246317 | Mt2 | Metallothionein 2 | 11.03 | 0.00042 | 0.01385 |
| A_51_P106059 | Traf4 | TNF receptor-associated factor 4 | 11.02 | 0.00198 | 0.03076 |
| A_55_P2162204 | Kctd15 | Potassium channel tetramerization domain containing 15 | 10.89 | 2.00E-05 | 0.00398 |
| A_55_P2162910 | Rtn1 | Reticulon 1 | 10.8 | 0.00015 | 0.0089 |
| A_55_P2024888 | Ctss | Cathepsin S | 10.75 | 0.00278 | 0.03756 |
| A_51_P474459 | Socs3 | Suppressor of cytokine signaling 3 | 10.67 | 5.00E-05 | 0.00575 |
| A_51_P501844 | Cyp26b1 | Cytochrome P450, family 26, subfamily b, polypeptide 1 | 10.59 | 0.00127 | 0.02434 |
| A_55_P2122020 | Klf4 | Kruppel-like factor 4 (gut) | 10.32 | 2.00E-05 | 0.00381 |
| A_55_P2105858 | Atf5 | Activating transcription factor 5 | 10.27 | 0 | 0.00012 |
| A_66_P126332 | Zfp703 | Zinc finger protein 703 | 10.12 | 0.00041 | 0.01382 |
| A_55_P2121856 | Ier5l | Immediate early response 5-like | 9.93 | 0.00046 | 0.01449 |
| A_51_P421140 | Tubb6 | Tubulin, β6 | 9.87 | 0.00023 | 0.01097 |
| A_51_P102789 | C1qc | Complement component 1, q subcomponent, C chain | 9.84 | 0.00378 | 0.04483 |
| A_55_P1971963 | Tmem176b | Transmembrane protein 176B | 9.62 | 0.00278 | 0.03756 |
| A_51_P258690 | Scrg1 | Scrapie responsive gene 1 | 9.61 | 0.00013 | 0.00835 |
| A_55_P1999902 | 9.6 | 4.00E-05 | 0.00485 | ||
| A_52_P597634 | Fzd1 | Frizzled homolog 1 (Drosophila) | 9.59 | 0.00013 | 0.00836 |
| A_55_P2098598 | Btg1 | B-cell translocation gene 1, anti-proliferative | 9.54 | 0.00029 | 0.01189 |
| A_55_P2003541 | Nrcam | Neuron-glia-CAM-related cell adhesion molecule | 9.53 | 1.00E-05 | 0.00333 |
| A_65_P19395 | H2-D1 | Histocompatibility 2, D region locus 1 | 9.12 | 3.00E-05 | 0.00436 |
| A_51_P159453 | Serpina3n | Serine (or cysteine) peptidase inhibitor, clade A, member 3N | 9 | 0.00228 | 0.0336 |
| A_55_P1953728 | Nes | Nestin | 8.75 | 0.00016 | 0.00914 |
| A_51_P502614 | Dusp6 | Dual-specificity phosphatase 6 | 8.72 | 1.00E-04 | 0.00758 |
* Student's t test.
† Benjamini–Hochberg test.