Table 1.
List of genes significantly deregulated after an acute challenge of l-DOPA
| Cluster A |
Cluster B |
||||||
|---|---|---|---|---|---|---|---|
| Peaked 1 h (UP) | Peaked 3 h (UP) | Peaked 3 h (DOWN) | |||||
| Egr4 | Per2 | Nedd4l | Ppp2r2d | Caskin2 | Erlin1 | Tax1bp3 | Vstm2a |
| Egr2 | Slc32a1 | Fkbp5 | Pkp2 | Atp2a2 | D430042O09Rik | C2cd4c | Fam113a |
| Per1 | Vgf | Prosapip1 | Ddit4l | Vti1b | Cdc42ep3 | BC046404 | Insc |
| Per1 | Gas7 | Cacna1 h | Abi2 | A930005I04Rik | Ndufa8 | Tmem141 | Epha5 |
| Npas4 | AI464131 | Ece1 | Zfp280d | Ppapdc2 | Eif4ebp2 | Pgpep1 | Fcgrt |
| Mfap3 | Arpp21 | Csmd3 | Smug1 | 2700062C07Rik | Rit2 | Chrm2 | Sypl |
| Dusp1 | Crym | Ntrk3 | C8b | Ubxn6 | Cacna2d3 | Tax1bp3 | Mela |
| Junb | Spry3 | 1110018G07Rik | Cinp | Wrb | Ccnyl1 | Araf | Nfatc3 |
| Arc | Syt4 | Sbk1 | Rerg | Sez6 | Zcchc12 | Hexb | Abca7 |
| Fos | Vdac1 | Car12 | Zfp385b | Spag6 | Foxp1 | Ctsb | Pgpep1 |
| FosB | Nrarp | Kcnd2 | Itgb1bp1 | Rab15 | Nptx2 | Rab8a | F11r |
| Dusp6 | Doc2b | Gabarapl1 | Kdm4b | Kcnab1 | Gng7 | Trappc1 | Wwtr1 |
| Frat2 | Camk1g | Zeb1 | Homer1 | Ippk | Nit1 | Vangl2 | Eif6 |
| Dusp6 | Fam184b | Slc25a44 | Vdac1 | Mbp | Lmtk2 | Vtn | Gns |
| Nab2 | Gdnf | Dmkn | Fdps | Chat | Foxo1 | Lpar4 | Syt12 |
| Ppp3r1 | Hpca | Ndufa5 | Sc4 mol | Astn1 | Tusc1 | Fam125a | |
| Pard6a | Nsg2 | Capn10 | 1810046J19Rik | Mpp6 | Tpm2 | Sp7 | |
| Gnb5 | Abi2 | Gne | Tmem41b | Psmc3ip | Lpar4 | Trib3 | |
| Taf9b | Ido1 | Zmynd8 | Unc119b | Prpf18 | Cmtm8 | Fam3a | |
| Dgkb | Gabrb3 | Ncor1 | 1110017D15Rik | Tiam2 | 41161 | Tex261 | |
| Gria2 | Ajap1 | Csrnp3 | Sf3a1 | Dmkn | 9130019O22Rik | Naprt1 | |
| Kcnab1 | Clic6 | Zfhx3 | Dcaf4 | Nphp4 | 3632451O06Rik | Slc2a6 | |
| Shank3 | Slc2a1 | Pfkp | 2610034M16Rik | Grid2 | Apba2 | 2810474O19Rik | |
| Nt5e | Dctn3 | Reln | Kcnk1 | Ifnar2 | Tmc6 | ||
| Per2 | Agfg2 | Dnajc2 | Banf1 | Egfl7 | 2210016L21Rik | ||
| Fam132a | Atg16l1 | Pde4dip | Tdrkh | Fam114a1 | Add3 | ||
| Tiam1 | Mat2a | Pitpnm3 | Slc22a17 | Cdc42ep2 | Pdgfa | ||
| Nt5e | Ubfd1 | 4833424O15Rik | Prkg2 | Plekho2 | Lor | ||
| Gucy1a3 | Tmem70 | Rem2 | Kdm5b | Gkap1 | Rnf135 | ||
| Kcna5 | Pptc7 | Ccrn4l | Fem1b | Lgals8 | |||
| Cluster C | |||||||
|---|---|---|---|---|---|---|---|
| Peaked 6 h (UP) |
Peaked 6 h (DOWN) |
||||||
| Lrrc1 | Znrf1 | Ppp1cc | Rgs14 | Sfxn3 | Sncb | Nav1 | Cln6 |
| Unc13c | Zfp930 | Casz1 | Rundc3b | Cyld | Aspscr1 | Plekha2 | Acta2 |
| Ino80e | Nsg2 | Sh3bgrl3 | Ylpm1 | Rhobtb2 | Tpd52 | Psap | Serac1 |
| Mfsd2a | Slmap | Hs6st2 | Slc2a13 | Chst11 | Hdac7 | Vamp1 | Rfc2 |
| Pdzd2 | H2afx | C1galt1c1 | Tac1 | 1110057K04Rik | Triobp | Metap1d | Adck4 |
| Syne1 | Ecel1 | Vldlr | Slc10a4 | Tmem199 | Tmem141 | Skap1 | BC017647 |
| Rap1gap | Ppp2r2a | Ppp2r2c | Penk | Grb10 | Aifm2 | Nol3 | Pld4 |
| Th | Dazl | Krt10 | Srm | Tle1 | Ptprd | Nos1ap | Tmed10 |
| Clip4 | Vldlr | Sorcs2 | Eps15l1 | Rhobtb2 | Ldb2 | Ptbp1 | Ccs |
| Pcsk2 | Musk | Arg2 | Ptk2b | Crtc1 | Reep3 | Tcf4 | Ednrb |
| Gpr158 | Lypd1 | Gpd1 | Ubl3 | Dab1 | Rab3d | Wipf1 | 2310003H01Rik |
| Lingo3 | Adra2c | Epb4.9 | Mterfd3 | Ets2 | Tmem106c | Npm3 | Sepn1 |
| Spock3 | Myo5b | Amigo2 | Rhbdl3 | Bahd1 | Tmc6 | Klf6 | Psap |
| Trnp1 | Mbnl2 | 4933424B01Rik | Slc25a14 | Wdr37 | Ptprd | Nol3 | Kcna6 |
| Smpd3 | 1110003E01Rik | Abi1 | Sdr39u1 | Cacnb2 | Cmtm4 | Vat1 | Hcls1 |
| Onecut2 | Cxx1c | Rasgrp1 | Vldlr | Mbnl2 | Alpl | Abhd14b | Kcne1l |
| Cyp2c44 | Gpr158 | Ddost | Strn | Mdga2 | Golim4 | Fam189a1 | Fam126a |
| Rarb | C030019I05Rik | Lrrtm3 | Slc2a13 | Pcdhgb4 | Fah | Tnfaip1 | Fam105b |
| Dlg2 | Jph3 | Sub1 | Fnip1 | Kdm3a | Glb1 | Ptbp1 | Btbd3 |
| Arpp19 | Rilp | Ccng2 | Ncbp1 | Spink8 | Pinx1 | Gpd2 | Dcakd |
| Ppp1r2 | Dgki | Trpc3 | Ndufs4 | Fbll1 | 1700084C01Rik | Fchsd1 | Gm4671 |
| Gdf10 | Tmcc2 | Pkia | Dixdc1 | Rilpl1 | Slc6a7 | Padi2 | |
| Trerf1 | Mxd1 | Vat1l | Zfp758 | Ube3c | Sox9 | Skp2 | |
| Ppp4r4 | Dlk1 | Coch | Zfp39 | Tmem49 | Slc38a2 | Nol3 | |
| Ramp1 | Gps1 | Wdr17 | Mtf2 | Cyp2a5 | Prkd3 | Nasp | |
| Mapkap1 | Pcsk2 | Scrn1 | B3galt5 | Pfn2 | Npm3-ps1 | Opalin | |
| E130309F12Rik | Scg5 | Zfp523 | Aplp1 | Myo1b | Gna13 | Nav1 | |
| Dbp | Gm5868 | Car12 | Lyar | Tbp | Ctnnbip1 | Pcyt2 | |
| Itpka | Ctxn1 | Ufsp1 | Ttyh1 | Ppp2r5e | Wnt7b | Parm1 | |
| Pcsk2 | Epor | Kars | Sipa1l3 | Ptgis | Mical1 | ||
| Cbr3 | Upb1 | Socs5 | Kdm3a | Srprb | Mobkl2a | ||
| Cluster D | |||||||
|---|---|---|---|---|---|---|---|
| UP 1–6 h |
DOWN 1–6 h |
||||||
| Nomo1 | Ppp1r1b | Klf16 | Gm10762 | Cldn5 | Ctsz | Igfbp2 | Lix1 |
| Dgat2 | Tsen2 | Mrps21 | Dennd1c | Ctsc | Dlgap1 | Gnas | Cotl1 |
| Ttc17 | Hnrnpl | Zfp281 | Fam38b | Map3k1 | Zeb2 | Slc29a3 | Fam81a |
| Ppp1r13b | Rundc3a | Ccbl1 | Satb1 | Stxbp1 | Syn1 | Vamp1 | Myo9b |
| Oaz2-ps | Inpp5f | Plk2 | Triobp | Cib2 | Il18bp | Il4i1 | Fadd |
| Fstl4 | 2010011I20Rik | Atxn1 | Slc22a18 | Fcgrt | Tcirg1 | Chrna4 | Tmem63b |
| Klf9 | Rpap2 | Ngef | Laptm5 | Klhl6 | Fes | Eif4g2 | Tnr |
| Arl3 | Scn4b | Tspan3 | Mmp14 | Cnih3 | 1700019N12Rik | Chchd8 | Naglu |
| Bai2 | Hras1 | Agpat1 | Cdkn1c | Pvalb | Gstm2 | Chac1 | 2210012G02Rik |
| Sec14l1 | Rpusd1 | Sap130 | Rab13 | Tnfrsf19 | Mitf | Axl | Cebpg |
| Gapdh | C2cd2l | Romo1 | Rell1 | Rassf5 | Rapgefl1 | Sh3pxd2b | Ncf4 |
| Hbegf | Ppp1r1b | Amz2 | Kcnc4 | Bicc1 | Ptprz1 | Lasp1 | Lamp2 |
| Scube3 | D2Wsu81e | Abcb8 | 2210411K11Rik | Sobp | Gabra3 | Pqlc2 | Vps13a |
| Cap1 | Fam196b | Rbak | Ptplad2 | Prickle1 | Plek | Iqgap1 | Robo2 |
| Gpc3 | Coro2b | Palm | Klhl6 | Iqgap1 | Lag3 | Slamf9 | 9030612E09Rik |
| Ubqln4 | Cox5b | Zfp704 | Slc24a6 | Hexa | Bbc3 | Tirap | Aggf1 |
| Sec14l1 | Meis2 | Siah2 | Fxyd5 | Mrpl48 | Arhgap4 | Palm2 | Mak16 |
| Taok1 | Gm129 | Darc | Col4a1 | Arhgef19 | P2ry6 | Paox | Hcst |
| Mrpl33 | Cry2 | Gdf1 | Cd200 | Lat2 | Pik3r1 | Htatip2 | Bach1 |
| Trnp1 | Cited4 | Rc3h2 | Slc44a2 | Plcg2 | Pik3cg | Myo9b | Pgm2l1 |
| Thoc4 | Sec14l1 | St8sia3 | Mef2c | Hecw1 | Ftl1 | Tab2 | H2-K1 |
| Tmem90a | Acy1 | Clec2d | S1pr2 | Stab1 | Tgoln1 | Grin1 | |
| Arap1 | Fbln1 | Pik3r1 | Pa2g4 | Ppm1l | |||
| Aif1 | Trim25 | Dpp7 | Hvcn1 | Crtac1 | |||
| Mef2c | Cyth4 | Hspb6 | Cask | Cd63 | |||
| Faah | Ctsz | Atp2a3 | 2410066E13Rik | 2700060E02Rik | |||
| Fadd | Mocs1 | Sobp | Shc1 | Rbl2 | |||
| Renbp | Gfap | 2810416G20Rik | Serpinb6a | Daam1 | |||
| Chst8 | Oasl2 | Hapln4 | Il11ra1 | Gabrg2 | |||
| Ranbp3l | Npc2 | Slc24a2 | Ccnd1 | Sepx1 | |||
| Igfbp5 | Arrb2 | Myl4 | Efna5 | Srpk3 | |||
| Lpp | Sox5 | Syn2 | Rsrc2 | Fxyd5 | |||
| Sh3gl2 | Fadd | Fcrls | St3gal5 | Fbln2 | |||
| Rims1 | Abi3 | Snx9 | Htatip2 | C4b | |||
| Cxcl12 | Rbm6 | Wdr1 | Pdcd4 | Oma1 | |||
| Ptprt | Nuak1 | Lmna | Adar | ||||
| Mapk11 | Ganc | C4a | Capg | ||||
| Tcirg1 | Gstm2 | Gatad2b | Il11ra1 | ||||
| Ltbp1 | Uap1l1 | Fgfr1op | C1qa | ||||
The regulated mRNAs are identified by their official gene symbol. Each cluster is identified by the direction (UP: up-regulated, DOWN: down-regulated) and the peak of deregulation (1, 3, or 6 h after injection of l-DOPA). Genes are then sorted among the cluster by p-values. Genes in bold are those used for Figure 2.