Figure 10.
H89 dihydrochloride does not modify the average GABAA single-channel conductance or the number of activated channels. A, B, Current–variance plot extracted from the peak scaled mIPSCs before and after H89 dihydrochloride application. Examples from a pseudo-trained rat cell (A) and a trained rat cell (B) are shown. In these examples, H89 dihydrochloride does not affect the single-channel current or the number of activated channels in the two neurons. C, The average GABAA single-channel conductance is not modified by the PKA blocker in the three groups. D, The average number of spontaneous events activated by GABAA channels is not modified by the drug in the three groups. Average values were calculated using 9 cells taken from 8 naive rats, 15 cells taken from 10 trained rats, and 9 cells taken from 6 pseudo-trained rats.