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. 2015 Jan 7;35(1):128–139. doi: 10.1523/JNEUROSCI.2123-14.2015

Figure 4.

Figure 4.

CaMKII reduces the single GABAA channel conductance in neurons from trained rats only. A, B, Current–variance plot extracted from the peak scaled mIPSCs before and after KN93 application. Examples from a pseudo-trained rat cell (A) and a trained rat cell (B) are shown. As evident from the initial slope of the parabola, KN93 reduced the single-channel current only in the trained neuron. C, The average GABAA single-channel conductance is significantly reduced after drug application only for neurons from trained rats. Values represent the mean ± SE (*p < 0.05). D, The average number of active GABAA channels per event is not modified by drug application in the three groups. Average values were calculated using 7 cells taken from 6 naive rats, 14 cells taken from 8 trained rats, and 9 cells taken from 5 pseudo-trained rats.