Figure 7.

The effect of PKC inhibitor on the amplitudes of mIPSCs is not learning dependent. A, Spontaneous inhibitory events recorded from neurons from a pseudo-trained rat (left) and a trained rat (right), before (top traces) and after (bottom traces) application of the PKC blocker GF109203X. The amplitude of events is reduced in both neurons. B, Amplitude histograms of the two neurons recorded in A. GF109203X has a detectable effect on the amplitude distribution in the two neurons (bottom histograms). Note that amplitudes of all events, large and small, are affected. C, The average amplitude if the inhibitory synaptic events is significantly reduced after GF109203X application in all three groups (*p < 0.05), as a result of which the difference in the average amplitude among the groups remained. Data taken from three trained, four naïve, and four pseudo-trained rats. D, GF109203X reduces the amplitude of events in the three groups.